Sophisticated methodologies for SE‘ reactions to afford stereocontrolled preparation of homoallylic alcohols have been studied for making highly functionalized systems to support applications to natural product chemisty. A brief outline of these efforts:
A) Bidirectional SE‘ strategies for 1,5-stereocontrol
Primary reference: Org. Lett. 2012, 14, 3866-3869.
B) Stereocontrol in Asymmetric SE‘ reactions of gamma-substituted α,β-unstaurated aldehydes
Primary reference: Org. Lett. 2014, 16, 468-471.
C) Bis-Stannylation of 1-Alkoxyallene and stereocontrolled allylation
Primary reference: J. Am. Chem. Soc. 2005, 127, 14550-14551.
D) Allylation SE‘ Reactivity of 3,3-Bis(trimethylsily)-2-methyl-1-propene.
Primary reference: Org. Lett. 2006, 8, 4393-4396.
E) The role of vicinal chirality in SE' reactions
Primary reference: Can. J. Chem. 2004, 82, 120-130.
F) Asymmetric SE’ reactions in the Total Synthesis of Phorboxazole A.
Primary reference: Proc. Natl. Acad. Sci. (USA) 2004, 101, 12058-12063.
G) Asymmertric SE’ reactions for the synthesis of Amphidinolide K.
Primary reference: J. Am. Chem. Soc. 2001, 123, 765-767.
H) Asymmertric SE’ reactions; an application for total synthesis of (−)-Laulimalide
Primary reference: Tet. Lett. 2002, 43, 4841-4844.
I) Asymmetric SE’ methodology for Total Synthesis of Leucascandrolide A.
Primary reference: Angew. Chem. Int. Ed. 2003, 42, 3934-3938.
J) Stereoconvergent SE’ reactions of chiral allylsilanes in the synthesis of Deoxyneodolabelline
Primary reference: J. Am. Chem. Soc. 2003, 125, 1843-1850.
K) Reagent-Controlled asymmertric allylation in the synthesis of Hennoxazole A.
Primary reference: J. Am. Chem. Soc. 1999,121, 4924-4925.