Asymmetric conjugate additions of cuprates

The methodology for asymmetric conjugate addition reactions has been explored for organocopper reagents. These studies have proven to be very useful in efforts to establish 1,3-syn and 1,3-anti stereochemistry in acyclic systems.


Primary references: Tet. Lett. 2002, 43, 3723-3727; Chem. Commun. 2003, 2220-2221.
Synthesis applications in capensifuranone: J. Org. Chem.  2004, 19, 5374-5382.
Efforts toward kendomycin: Org. Lett. 2005, 7, 4161-4164.
Examples in the synthesis of (+)-sambutoxin: Org. Lett. 2000, 2, 3217-3220.